Sintrom  

Acenocoumarol
Systematic (IUPAC) name
4-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-chromen-2-one
Identifiers
CAS number	152-72-7
ATC code	B01AA07
PubChem	9052
ChemSpider	10443441
Chemical data
Formula	C19H15NO6
Mol. mass	353.326 g·mol-1
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	?
Metabolism	Hepatic
Half life	8 to 11 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	POM(UK)
Routes	Oral
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Acenocoumarol is an anticoagulant that functions as a vitamin K antagonist (like warfarin). It is a derivative of coumarin and is marketed under the brand names Sintrom and Sinthrome.

External links

• DDB 29202
• Cesar J, García-Avello A, Navarro J, Herraez M (2004). "Aging and oral anticoagulant therapy using acenocoumarol.". Blood Coagul Fibrinolysis 15 (8): 6736. doi:10.1097/00001721-200412000-00007. PMID 15613922. 
• Lengyel M (2004). "Warfarin or acenocoumarol is better in the anticoagulant treatment of chronic atrial fibrillation?". Orv Hetil 145 (52): 261921. PMID 15724697. 
• Ufer M (2005). "Comparative pharmacokinetics of vitamin Kd antagonists: warfarin, phenprocoumon and acenocoumarol.". Clin Pharmacokinet 44 (12): 122746. doi:10.2165/00003088-200544120-00003. PMID 16372822. 
• Montes R, Ruiz de Gaona E, Martínez-González M, Alberca I, Hermida J (2006). "The c.-1639G > A polymorphism of the VKORC1 gene is a major determinant of the response to acenocoumarol in anticoagulated patients.". Br J Haematol 133 (2): 1837. doi:10.1111/j.1365-2141.2006.06007.x. PMID 16611310. 

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Recent Sintrom Forums  View All  

Sex Ansd Sintrom will there be any side effects that will affect my husband having an erection or being able to have a normal sex life? Also how much alcohol is considered harmfull when taking sintrom Thursday, 11/19/2009 6:27:02 PM  1 Reply

Dosage Of Sintrom My father has INR 1.43. He has taken 1,1, 2 mg sintrom in three consecutive days. How mg sintrom will he take in matter his INR to be 2-3? Please ask to me as soon as you can. Thank You Wednesday, 8/12/2009 1:11:18 PM  1 Reply

Sintrom Dosage I am 74 years old. I am using Sin trom about 2 years, after implementation of the Pacemaker due to arithima absoluta. I have difficulties to maintain recomennded level of INR, between 2 and 3. During those 2 years I had tried with different dosage schedulle - changing dosage from 1 - 2 mg per day. For example: 2-2-2-1; 2-2-2-2-1; 2-1-2-1-2 etc. I have measured INR regularly at home with CoaguChek Roshe apparatus, or in professional labs, every week or more frequently depending on the oscilation of INR. Up to now I did not succseded to find proper dosage which can maintain INR in the range 2-3, nor can find reason for so unexpected oscilations in INR. No new medications, or life style changes have happened during this period. Thursday, 8/6/2009 2:37:47 PM  Post a Reply