Irbesartan  

Irbesartan

Systematic (IUPAC) name
2-butyl-3-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1,3-diazaspiro[4.4]non-1-en-4-one
Identifiers
CAS number	138402-11-6
ATC code	C09CA04
PubChem	3749
DrugBank	APRD00413
Chemical data
Formula	C25H28N6O
Mol. mass	428.53
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	6080%
Metabolism	Hepatic (CYP2C9)
Half life	1115 hours
Excretion	Renal 20%, faecal 65%
Therapeutic considerations
Licence data	EU EMEA:link, US FDA:link
Pregnancy cat.	D (Au)
Legal status	S4 (Au), POM (UK), -only (U.S.)
Routes	Oral

Irbesartan (INN) (pronounced /rbsrtn/) is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. Irbesartan was developed by Sanofi Research (now part of sanofi-aventis). It is jointly marketed by sanofi-aventis and Bristol-Myers Squibb under the trade names Aprovel, Karvea, and Avapro.

Clinical use

Indications

As with all angiotensin II receptor antagonists, irbesartan is indicated for the treatment of hypertension. Irbesartan may also delay progression of diabetic nephropathy and is also indicated for the reduction of renal disease progression in patients with type 2 diabetes,^[1] hypertension and microalbuminuria (>30 mg/24 hours) or proteinuria (>900 mg/24 hours).^[2]

Combination with diuretic

Irbesartan is also available in a combination formulation with a low dose thiazide diuretic, invariably hydrochlorothiazide, to achieve an additive antihypertensive effect. Irbesartan/hydrochlorothiazide combination preparations are marketed under similar trade names to irbesartan preparations, including Irda, CoIrda, CoAprovel, Karvezide, Avalide and Avapro HCT.

No benefits seen for

A large randomized trial following 4100+ men and women with heart failure and normal ejection fraction (>=45%) over 4+ years found no improvement in study outcomes or survival with irbesartan as compared to placebo.^[3]

Market

BMS annual sales approx $1.3bn. Sanofi-aventis annual sales approx $2.1bn. Patent expires in 2011.

References

See also

• Angiotensin II receptor antagonist

Recent Irbesartan Forums  View All  

Can Cessation Of Avapro(irbesartan) Cause Anxiety? I have noticed unusual symptoms if I forget to take my 225mg dose of Avapro in the morning(which I've done on 3 or 4 occasions over the past 2 years). Also, I recently lowered the dose to 150mg. After 4 days of this, I was in a very nervous state. Because the nervousness was becoming unbearable, halfway through the 4th day of just taking the 150mg, I decided to take the 75mg tablet as well to bring me up to my regular daily dose and, within an hour, my nervousness subsided. Has anybody else had a similar experience? Tuesday, 12/2/2008 9:42:55 AM  1 Reply

Irbesartan/hctz New Medication, trying to find the side effects. Friday, 1/27/2006 12:15:41 PM  Post a Reply

Shortness Of Breath I HAVE SHORTNESS OF BREATH &SWELLING IN LEFT FOOT Tuesday, 12/27/2005 8:18:09 AM  2 Replies

What Medical Conditions Does Irbesartan Treat? My husband has just started taking Irbesartan in the form of Avapro. What medical conditions does this medication treat? Tuesday, 7/5/2005 8:46:00 AM  Post a Reply