Ibandronate  

Ibandronic acid
Systematic (IUPAC) name
{1-hydroxy-3-[methyl(pentyl)amino]propane-1,1-diyl}bis(phosphonic acid)
Identifiers
CAS number	114084-78-5
ATC code	M05BA06
PubChem	60852
DrugBank	APRD00231
Chemical data
Formula	C9H23NO7P2
Mol. mass	319.229 g/mol
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	0.6%
Protein binding	90.9 to 99.5% (concentration-dependent)
Metabolism	Nil
Half life	10 to 60 hours
Excretion	Renal
Therapeutic considerations
Licence data	EU EMEA:link, US FDA:link
Pregnancy cat.	C(US)
Legal status	Prescription only
Routes	Oral, intravenous

Ibandronic acid (INN) or ibandronate sodium (USAN), marketed under the trade names Boniva, Bondronat and Bonviva, is a potent bisphosphonate drug used in the prevention and treatment of osteoporosis.^[1]

It may also be used to treat hypercalcemia (elevated blood calcium levels). It is Marketed and Manufactured by GlaxoSmithKline and Roche Laboratories. Global sales in 2008 were 1.1B CHF ($1.0B USD at 01/01/2009 exchange rates).^[2]

Indications

Ibandronate is indicated for the treatment and prevention of osteoporosis in post-menopausal women. Men should not take ibandronate unless they are participating in clinical trials. In May 2003, the U.S. Food and Drug Administration (FDA) approved Ibandronate as a daily, 2.50 mg dose treatment for post-menopausal osteoporosis. The basis for this approval was a three-year, randomized, double-blind, placebo-controlled trial of 2,946 women suffering post-menopausal osteoporosis. The participants received either a placebo or an oral ibandronate dose (2.50 mg), or intermittently (20 mg every second day in 12 doses at the beginning of each 3-month interval). Every participant also received daily oral doses of 500 mg of calcium and 400IUs [international units] of vitamin D. At the study's conclusion, both doses significantly reduced the occurrence risk of new vertebral fractures by 5052 per cent when compared to the effects of the placebo drug.

References

External links

• Boniva Osteoporosis Treatment by GlaxoSmithKline and Roche Laboratories
• Boniva Side Effects Reported by Users

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