Fanapt  

Iloperidone
Systematic (IUPAC) name
1-[4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1- piperidinyl]propoxy]-3-methoxyphenyl]ethanone
Identifiers
CAS number	133454-47-4
ATC code	none
PubChem	71360
Chemical data
Formula	C24H27FN2O4
Mol. mass	426.481g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	~95%
Metabolism	hepatic (CYP2D6 and CYP3A4)
Half life	18-33 hours
Excretion	urine and feces
Therapeutic considerations
Pregnancy cat.	?
Legal status	-only(US)
Routes	Oral, injection

Iloperidone, also known as Fanapt, Fanapta, and previously known as Zomaril, is an atypical antipsychotic for the treatment of schizophrenia. It was approved by the U.S. Food and Drug Administration (FDA) for use in the United States on May 6, 2009.

Pharmacology

Iloperidone is a monoamine directed towards acting upon and antagonizing specific neurotransmitters. It is considered as an atypical antipsychotic that is less likely to cause movement disorders in patients when compared to tradition methods of psychotic treatment. Like the other FDA-approved atypical antipsychotics, iloperidone acts on both dopamine and serotonin receptors.^[1]

Iloperidone has been shown to act as an antagonist at all tested receptors. It was found to block the sites of noradrenaline (_2C), dopamine (D_2A and D₃), and serotonin (5-HT_1A and 5-HT₆) receptors.^[2]

Laboratory studies

Iloperidone performed well against a prepulse inhibition (PPI) experiment, which was designed to gauge the extent of psychotic disorders in rats. Prepulse inhibition is the reduction in the amount of startle the subject gives when presented with a non-startling stimulus. Those exhibiting high levels of psychosis present a deficit in PPI. Psychosis induced using PCP, apomorphine, and cirazoline, were all prevented with the concurrent administration of iloperidone. The PPI deficit normally incurred by each psychotic drug was significantly diminished by the co administration of iloperidone.^[3] The results of this experiment provided strong evidence for iloperidones merit as an effective treatment for psychotic disorders. Iloperidone has also been shown to reduce the effects of apomorphine induced climbing behavior in mice as well as the effects of head twitching induced by 5-HT in rats.^[4]

Clinical studies

Clinical studies have shown that some patients treated with iloperidone show reduced extrapyramidal symptoms and weight gain. Phase II testing has shown that effectiveness in humans is possible with as low as 8mg per day, and is tolerable up to 32mg per day.

Side effects

Examination of the safety and tolerability of iloperidone have shown that at a 5mg/day dose in healthy male volunteers, the drug was fairly well tolerated, although hypotension, dizziness, and somnolence were very common side effects ranging from mild to moderate in severity. A second study showed that co administration of food decreased the severity of these effects. This study also indicated that repeat administration of iloperidone could decrease the effects of hypotension.^[5]

Dosage

Vanda Pharmaceuticals has stated that they are developing both oral and injectable formulations. The injectable formulation is being developed to be administered at four week intervals.

Regulatory approval

Hoechst Marion Roussel Inc. made initial inquiries into the drug; however, in May 1996, they discontinued research, and in June 1997 gave research rights to Titan Pharmaceuticals. Titan then handed over worldwide development, manufacturing and marketing rights to Novartis in August 1998. On June 9, 2004, Titan Pharmaceuticals announced that the Phase III development rights have been acquired by Vanda Pharmaceuticals. The original launch date was scheduled for 2002. On November 27, 2007, Vanda Pharmaceuticals announced that the U.S. Food and Drug Administration (FDA) had accepted their New Drug Application for iloperidone, confirming the application is ready for FDA review and approval.^[6] On July 28, 2008, the FDA issued a "Not Approvable" letter to Vanda Pharmaceuticals concerning the drug, stating that further trials are required before a decision can be made concerning marketed usage of iloperidone.^[7]

Iloperidone won FDA approval for use treating schizophrenia in the United States on May 6, 2009.^[8]

References

External links

• Fanapt Web Site
• Fanapt PI Sheet