Dicumarol  

Dicoumarol

Systematic (IUPAC) name
3,3'-methylenebis(4-hydroxy-2H-chromen-2-one)
Identifiers
CAS number	66-76-2
ATC code	B01AA01
PubChem	653
DrugBank	APRD00761
Chemical data
Formula	C19H12O6
Mol. mass	336.295 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	plasmatic proteins
Metabolism	hepatic
Half life	?
Excretion	faeces, urine
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?
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Dicoumarol (INN) or dicumarol (USAN) is an anticoagulant that functions as a Vitamin K antagonist (similar to warfarin). It is also used in biochemical experiments as an inhibitor of reductases. Dicoumarol is a chemical substance of plant origin, a derivative of coumarin. It is given only orally, and it acts within two days.

Mechanism of action : it is a competitive inhibitor of Vitamin K preventing the formation of prothrombin. Administration of Vitamin K is the antidote for dicoumarol toxicity. Follow-up is done by measuring the Prothrombin time (PT).

Uses: Used along with heparin for the treatment of deep venous thrombosis

External links

• DDB 30166
• Cullen J, Hinkhouse M, Grady M, Gaut A, Liu J, Zhang Y, Weydert C, Domann F, Oberley L (2003). "Dicumarol inhibition of NADPH: quinone oxidoreductase induces growth inhibition of pancreatic cancer via a superoxide-mediated mechanism.". Cancer Res 63 (17): 551320. PMID 14500388. 
• Mironov A, Colanzi A, Polishchuk R, Beznoussenko G, Mironov A, Fusella A, Di Tullio G, Silletta M, Corda D, De Matteis M, Luini A (2004). "Dicumarol, an inhibitor of ADP-ribosylation of CtBP3/BARS, fragments golgi non-compact tubular zones and inhibits intra-golgi transport.". Eur J Cell Biol 83 (6): 26379. doi:10.1078/0171-9335-00377. PMID 15511084. 
• Abdelmohsen K, Stuhlmann D, Daubrawa F, Klotz L (2005). "Dicumarol is a potent reversible inhibitor of gap junctional intercellular communication.". Arch Biochem Biophys 434 (2): 2417. doi:10.1016/j.abb.2004.11.002. PMID 15639223. 
• Thanos C, Liu Z, Reineke J, Edwards E, Mathiowitz E (2003). "Improving relative bioavailability of dicumarol by reducing particle size and adding the adhesive poly(fumaric-co-sebacic) anhydride.". Pharm Res 20 (7): 1093100. doi:10.1023/A:1024474609667. PMID 12880296. 

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