Hypertension And Sleeping
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I am 65 and have had hypertension treated sucessfully with Ibestartin 300/12.5, Amlodine 5mg and perindopril 5mg very successfully.
Six weeks I had an emergency admission to hospital with incapacitating leg pain.and as a result had a microdiscectomy and forminotomy operation which was successful.
As i have always monitored my BP I was concerned to see my BP increase to levels around 170/90.
My doctor changed my medication to Coveram 10x10mg to counter this in place of Amlodopine and Perindopril, which I understand and agree with.
Can you advise when results might be reasonably be seen with this increase in dosage.
Also I take Zolpidem 5mg and as this is not always effective am considering also taking 2mg of Circadin prescribed by my doctor rather than increase Zolpidem. Is this a reasonable approach.
Finally are there any contraindications between the above and Doxylamine 25mg.
My plan would be to finally drop Zolpidem and just use Circadin and/or Doxylamine.

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Hi David,
Thanks for your help. I have had a good relationship with my doctor for nearly 30 years,
and he supports me in researching new drug regimes that could be applicable. I look forward to reading anything that may help me understand issues pertaining to my health. Thanks again.
Mark

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Hi Mark,

To help address a couple of your questions, Coveram is just another brand name of the Amlodopine and Perindopril combination you were previously taking before the switch. So it may not end up taking long at all for the active ingredients to get built back up in your system. In which case, I would "anticipate" seeing a noticeable difference well within the first few days to a week.

As far as contraindications are concerned, Zolpidem is said to interact with the Doxylamine as well as the Perindopril found in Coveram.

Apparently, using either of these medications together can increase your risk of side effects (such as impairment in thinking or judgment, dizziness, drowsiness, and/or difficulty concentrating). Perindopril and zolpidem may also have additive effects in lowering your blood pressure if taken together. Some side effects of low blood pressure can include: headaches, dizziness, lightheadedness, fainting, and/or changes in pulse or heartrate. So that's just one other thing to remain aware of until you're able to successfully drop the Zolpidem.

From what I've read, the interactions mentioned above would most likely be seen at the beginning of one's treatment following a dosage increase, or when treatment is restarted after an interruption. That said, it's really important to let your doctor know if you happen to develop any bothersome symptoms that do not go away after a few days.

I hope this info helps!

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